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Nitric oxide then activates the enzyme guanylate cyclase, which results in improved amounts of cyclic guanosine monophosphate (cGMP), making easy muscle mass rest in the corpus cavernosum and permitting inflow of blood .The AUC on the active metabolite, N-desmethyl Edegra, was enhanced sixty two% by loop and potassium-sparing diuretics and 102% by

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